Canesoral Duo Vaginal Thrush Treatment

Canesoral Duo is a convenient 2-in-1 answer to thrush relief – combining a single oral capsule to treat thrush and a cream to relieve the discomfort. From the makers of Canesten, the trusted name in thrush treatment.

For vaginal thrush in adults, only a single dose (1 capsule) is needed.

Swallow the capsule whole with a glass of water. The capsule can be taken with or without food.

Use the cream on the external irritated area 2-3 times a day to relieve the symptoms for as long as they last, usually not more than 3 days.

Do not give CANESORAL DUO to children under 18 years of age except under doctor supervision.

When you must not use it

Do not use CANESORAL DUO if you are allergic to medicines containing:

• fluconazole
• clotrimazole
• other azole antifungals such as miconazole (e.g. Daktarin), ketoconazole (e.g. Nizoral), itraconazole (e.g. Sporanox)
• any of the ingredients listed at the end of this leaflet.

Some of the symptoms of an allergic reaction may include skin rash, itching or hives; swelling of the face, lips or tongue which may cause difficulty in swallowing or breathing; wheezing or shortness of breath.

Do not use CANESORAL DUO if you are taking cisapride (Prepulsid), a medicine used to treat stomach problems. Combining CANESORAL DUO with cisapride may cause serious side effects such as an abnormal heart rhythm.

Do not use CANESORAL DUO if you are pregnant, suspect you may be pregnant or if you may become pregnant during treatment. CANESORAL DUO should not be used during pregnancy as it may affect your developing baby.

Do not use CANESORAL DUO if you are breastfeeding. Fluconazole passes into breast milk and may affect your baby.

Do not use CANESORAL DUO if the expiry date (EXP) printed on the pack has passed.

Do not use CANESORAL DUO if the packaging shows signs of tampering; the capsule does not look quite right or the cream tube shows signs of tampering.

If you are not sure whether you should start using this medicine, talk to your doctor or pharmacist.

Before you start to use it

Tell your doctor or pharmacist if you are allergic to any other medicines, foods, dyes or preservatives.

Tell your doctor or pharmacist if you have or have had, any medical conditions, especially the following:

• thrush more than twice in the last six months
• liver problems
• kidney problems
• heart problems
• HIV infection or AIDS.
• diabetes

Your doctor or pharmacist may want to take special care if you have any of these conditions.

Tell your doctor or pharmacist before using CANESORAL DUO if you are taking warfarin (eg. Marevan, Coumadin), as bleeding or bruising may occur.

Tell your doctor or pharmacist if you are experiencing any of the following:

• Abnormal or irregular vaginal bleeding or blood stained discharge
• Foul smelling or unusual coloured discharge
• Vulval or vaginal sores, ulcers or blisters
• Lower abdominal pain or burning when passing urine
• Fever or chills

If you have not told your doctor or pharmacist about any of the above, tell them before you start using CANESORAL DUO.

Using the CANESTEN CLOTRIMAZOLE CREAM component of CANESORAL DUO may reduce the effectiveness and safety of latex products, such as condoms and diaphragms. This effect is temporary and occurs only during treatment.

Taking other medicines

If you are taking cisapride (Prepulsid), a medicine used to treat stomach problems, do not use CANESORAL DUO.

Tell your doctor or pharmacist if you are taking any other medicines, including any that you buy without a prescription from a pharmacy, supermarket or health food shop.

Some medicines may be affected by CANESORAL DUO, or may affect how well it works. These include:

• warfarin (e.g. Marevan, Coumadin), a medicine used to prevent blood clots
• phenytoin (e.g. Dilantin), a medicine used to treat epilepsy
• cyclosporin (eg. Neoral) or tacrolimus (e.g. Prograf), medicines used to prevent organ transplant rejection or to treat certain problems with the immune system
• certain medicines use to treat diabetes such as:
• glibenclamide (e.g. Daonil, Glimel), glipizide (e.g. Minidiab, Melizide), glimepiride (e.g. Amaryl), gliclazide (e.g. Diamicron, Glyade)
• pioglitazone (e.g. Actos), rosiglitazone (e.g. Avandia)
• rifampicin (e.g. Rifadin, Rimycin) or rifabutin (e.g. Mycobutin), antibiotics used to treat infections
• theophylline (e.g. Nuelin), a medicine used to treat asthma
• midazolam (e.g. Hypnovel) and triazolam (e.g. Halcion), medicines used as sedatives or to treat anxiety
• zidovudine (e.g. Retrovir), a medicine used to treat AIDS
• hydrochlorothiazide (e.g. Dithiazide), a medicine used for treating fluid problems and high blood pressure
• the contraceptive pill (birth control pill).

Talk to your doctor about the need for an additional method of contraception while using CANESORAL DUO. CANESORAL DUO may decrease the effectiveness of some birth control pills.

Your doctor can tell you what to do if you are taking any of these medicines.

If you are not sure whether you are taking any of these medicines, check with your doctor or pharmacist. Your doctor and pharmacist have more information on medicines to be careful with or avoid while using CANESORAL DUO.

The active ingredient in the CANESORAL capsule is fluconazole 150 mg.

Each capsule also contains the following inactive ingredients:

• gelatin
• lactose
• pregelatinised maize starch
• silicon dioxide
• magnesium stearate
• sodium lauryl sulfate
• titanium dioxide (E171)
• TekPrint SW-9008 Black Printing Ink
• TekPrint SW-9009 Black Printing Ink.

The active ingredient in CANESTEN CLOTRIMAZOLE CREAM is 10 mg clotrimazole per gram of cream as the active ingredient.

The cream also contains:

• sorbitan monostearate
• Polysorbate 60
• Cetyl palmitate
• Cetostearyl alcohol
• octyldodecanol
• benzyl alcohol
• purified water

This medicine does not contain sucrose, gluten, tartrazine or any other azo dyes